Mean patient age in years (+/- SD, range):54.07 (39 to 68)
Back only or predominant:7
Back and leg(s):15 (designated as back and limb)
Failed back surgery syndrome:13 (including 1 designated as failed neck)
Spinal cord injury:2 myelopathy
Number patients who underwent trial:15
Trial electrode type:Lamitrode
Trial electrode manufacturer:St. Jude
Pain control during trial:General anesthesia
Length of hospitalization:Discharged on 2nd postoperative day
Trial duration (days):Minimum 28 days
Paresthesia coverage:Determined with initial tonic stimulation. Limb pain covered in all patients.
Stimulation programming methods:After initial tonic stimulation, patients randomly received burst, tonic, or placebo for a week each. Wash-out assumed to occur when pain returned after stimulation turned off before next type of stimulation turned on.
Parameters:Patient chose best stim intensity. Burst = amplitude below paresthesia threshold; 40-Hz burst mode with 5 spikes at 500 Hz per burst, 1ms and 1ms interspike interval constant current, cumulative charge of 5 spikes balanced during 5 ms interval after the spikes (differentiating burst from intermittent HF stim); placebo stim intensity decreased to zero amplitude.
Electrode location(s):14 thoracic; 1 cervical
Number in study:15
Answer to study question:No effect from order in which type of stimulation was delivered; burst had significantly better impact vs. others on least/worst pain; on EEG, burst led to increased activation of 'dorsal anterior cingulate and right dorsolateral prefrontal cortex' vs. tonic; no significant difference between burst and placebo in terms of paresthesia elicited. SCS leads to increased pain relief vs. placebo.
Data presented disaggregated and summarized?:Yes
Mean pain reduction:Placebo 10.9%; tonic 30.9%; burst 55.0% (significant difference between placebo/tonic and burst)
Pain reduced back:Placebo 18.9%; tonic 51.1%; burst 51.3% (significant difference between placebo and burst)
Pain reduced legs:(Limbs) placebo 11.7%; tonic 30.9%; burst 55.0% (significant difference between placebo and tonic/burst)
Other beneficial outcomes
Change in quality of life:Only burst had significant impact on attention pts gave to pain.
Stimulation side effects
Faculty and staff
Facility location:New Zealand; Belgium
Data extraction information
Submitted by/date submitted:JS Feb 2014